The millionaire business tycoons, who have purchased 6,000 petrol station forecourts around the world as well as the Big 4 grocer just over a year ago, are in early discussions over the adding Boots to its portfolio.
The news comes as last week Bain Capital and CVC Capital Partners placed a joint bid for the beauty retailer, which employs 50,000 employees and is said to be worth as much as £10 billion.
According to Sky News, Bain and CVC were being advised by bankers at Lazard on their interest in Boots.
The discussions by the Issa brothers come after they sealed a £6.8 billion takeover bid of Big 4 grocer Asda last year.
They borrowed £3.5 billion to finance the bid and planned to sell the grocer’s petrol stations to EG Group, their sister company.